𝔖 Bobbio Scriptorium
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A molybdenum-containing dehydrogenase catalyzing an unusual 2-hydroxylation of nicotinic acid

✍ Scribed by T. Schräder, B. Thiemer, J. Andreesen


Book ID
105949050
Publisher
Springer
Year
2002
Tongue
English
Weight
67 KB
Volume
58
Category
Article
ISSN
1432-0614

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## Abstract Hybrid meta‐GGA density functional theory (the MPWB1K functional) was used to study the hydroxylation and ring‐opening mechanism of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid oxygenase (MHPCO). This enzyme catalyses the conversion of 2‐methyl‐3‐hydroxypyridine‐5‐carboxylic acid (MHPC)