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A molecular orbital study of the reaction catalysed by the enzyme adenosine kinase and its active site

✍ Scribed by José Kaneti


Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
643 KB
Volume
38
Category
Article
ISSN
0022-5193

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MO-Studies of enzyme reaction mechanisms
✍ Alexander Alex; Timothy Clark 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 930 KB

Ab initio and semiempirical (AMl) molecular orbital theory has been used to model the cleavage of formamide at the active site of carboxypeptidase A. The model active site consists of a zinc dication coordinated to two imidazoles, an acetate, a water with a hydrogen-bonded formate, and a formamide m