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A molecular model for ion selectivity in membrane channels

✍ Scribed by H. Schröder

Publisher
Springer
Year
1985
Tongue
English
Weight
694 KB
Volume
11
Category
Article
ISSN
1432-1017

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✦ Synopsis

In this article, the three-dimensional motion of an ion within a molecular channel is discussed for the first time; escape rates from binding sites are calculated using the transition state method. For a given ligand configuration and a particular pore radius the rates depend upon ion size and mass. It is found that the activation energies depend strongly on the ion size, i.e., they increase with decreasing ion radius. In contrast to the rates obtained from the mass dependence alone, the rates depending on both mass and size of the alkali ions yield the completely inverted sequence, namely the Eisenman sequence I.

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