A Molecular Dynamics Study of the Stereoselective Interaction between an Enantiomeric Amino-Acid Ester and an l-Histidine-Containing Catalyst in the Bilayer Membrane

The role of membrane-promoted multi-poin

The role of membrane-promoted multi-point hydrophobic interactions between peptide catalysts and enantiomeric substrates in highly stereoselective hydrolyses of amino acid esters

✍ Katsutoshi Ohkubo; Kenji Urabe; Junji Yamamoto; Satoshi Usui; Takashi Sagawa 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 296 KB

The 500 MHz 'H NMR NOESY spectra of membrane-promoted multi-point hydrophobic interactions between peptide catalysts and enantiomeric amino acid esters were detected for clarifying the role of muti-point interactions between the reactants in the highly stereoselective hydrolysis reactions in a vesic