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A Molecular Dynamics Simulation of the Binding Modes of d -Glutamate and d -Glutamine to Glutamate Racemase

✍ Scribed by Puig, Eduard; Garcia-Viloca, Mireia; González-Lafont, Àngels; López, Inés; Daura, Xavier; Lluch, José M.


Book ID
127050116
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
611 KB
Volume
1
Category
Article
ISSN
1549-9618

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## Abstract Synaptic increase of glutamate level, when not coupled to a heightened energy production, renders neurons susceptible to death. Astrocyte uptake and recycling of synaptic glutamate as glutamine is a major metabolic pathway dependent on energy metabolism, which interrelationships are not