Effect of phosphorothioate chirality on
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Shayantani Mukherjee; Dhananjay Bhattacharyya
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Article
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2004
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Wiley (John Wiley & Sons)
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English
β 453 KB
π 2 views
## Abstract Phosphorothioate oligonucleotides (PSβODNs) have gained considerable attention in drug therapy, primarily as potent antisense or antigene oligomers, which bind to specific DNA or mRNA sequences and lead to transcriptional or translational arrest. These are obtained by substituting one o