✦ LIBER ✦

A Modular Approach to a New Class of Monodentate Chiral Phosphorus Ligands and Their Application in Enantioselective Copper-Catalysed Conjugate Additions of Diethylzinc to Cyclohexenone

✍ Scribed by Chiara Monti; Cesare Gennari; Rebecca M. Steele; Umberto Piarulli

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 172 KB
Volume: 2004
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200400227

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new family of chiral phosphorus ligands (5) for use in enantioselective catalysis have been synthesised. The ligands contain the electron‐poor bis(sulfonyl)diazaphospholidine moiety and possess a highly modular structure which is well suited to the synthesis of a library. A small library (23 members) of ligands 5 was prepared and tested in the enantioselective copper‐catalysed conjugate addition of diethylzinc to cyclohexenone. Complete conversions were obtained with enantiomeric excesses (ee) of up to 75%. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

📜 SIMILAR VOLUMES

Development of New Chiral P,N Ligands an

Development of New Chiral P,N Ligands and Their Applications in Enantioselective 1,4-Conjugate Additions of Diethylzinc to Chalcones.

✍ Yuxue Liang; Shuang Gao; Huihui Wan; Yuanchun Hu; Huilin Chen; Zhuo Zheng; Xinqu 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 186 KB 👁 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Convenient Synthesis of a New Class of C

Convenient Synthesis of a New Class of Chiral Hydroxymethyldihydrooxazole Ligands and Their Application in Asymmetric Addition to Diethylzinc to Aromatic Aldehydes.

✍ Zhi-ting Li; Xin-sheng Li; Liang-chao Li; Dong-cheng Xu 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB 👁 2 views

Development of New Chiral P,N Ligands an

Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones

✍ Xinquan Hu; Huilin Chen; Xumu Zhang 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 2 views

ChemInform Abstract: Synthesis of a New

ChemInform Abstract: Synthesis of a New Class of Chiral Amino Alcohols and Their Application in the Enantioselective Addition of Diethylzinc to Aldehydes.

✍ Nieves Arroyo; Ulrike Haslinger; Kurt Mereiter; Michael Widhalm 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

ChemInform Abstract: Development of New

ChemInform Abstract: Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones

✍ Xinquan Hu; Huilin Chen; Xumu Zhang 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Synthesis of New Chiral Aryl Diphosphite

Synthesis of New Chiral Aryl Diphosphite Ligands Derived from Pyranoside Backbone of Monosacharides and Their Application in Copper-Catalyzed Asymmetric Conjugate Addition of Diethylzinc to Cyclic Enones

✍ Lailai Wang; Yue-Ming Li; Chiu-wing Yip; Liqin Qiu; Zhongyuan Zhou; Albert S. C. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 2 views

## Abstract New chiral aryl diphosphite ligands based on the pyranoside backbones of glucose and galactose were prepared. These ligands were tested in the Cu‐catalyzed asymmetric conjugate addition of diethylzinc to cyclic enones with up to 88% ee. The stereoselectivity was found to be dependent on