Screening for nonsense mutations in pati
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Alexander P. Reiner; Arthur R. Thompson
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Article
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1992
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Springer
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English
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Despite marked genetic heterogeneity in families with hemophilic patients, transition mutations in CG dinucleotides occur frequently. Of 71 CG dinucleotides in the factor VIII cDNA, a C-to-T transition in 12 would lead to a new Stop codon (CGA to TGA). Using restriction enzyme digestion of 11 amplif