A Modified Equilibrium Dialysis Technique for Measuring Plasma Protein Binding: Experimental Evaluation with Diazepam and Nortriptyline

Development and validation of a 96-well

Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding

✍ Michael J. Banker; Tracey H. Clark; John A. Williams 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

A 96-well equilibrium dialysis block was designed and constructed that is compatible with most standard 96-well format laboratory supplies and instruments. The unique design of the dialysis apparatus allows one to dispense and aspirate from either or both the sample and dialysate sides from the top