✦ LIBER ✦
A modified backbone amide linker (BAL) solid-phase peptide synthesis strategy accommodating prolyl, N-alkylamino acyl, or histidyl derivatives at the C-terminus
✍ Scribed by Jordi Alsina; T.Scott Yokum; Fernando Albericio; George Barany *
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 116 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new variation of the Backbone Amide Linker (BAL) approach has been developed for N a -Fmoc solidphase synthesis (SPS) of C-terminal modi®ed peptides; this provides a convenient route to peptides containing prolyl, N-alkylamino acyl, or histidyl derivatives at the C-terminus. To illustrate the principles, several model peptides were prepared in high yields and excellent purities; diketopiperazines and racemized byproducts which otherwise form when alternative procedures are used were absent from the syntheses reported herein.