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A model study for a novel synthetic approach to 2-carboxyinosines

✍ Scribed by Vasanthakumar Rajappan; Ramachandra S Hosmane

Book ID: 104211272
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 87 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01725-1

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✦ Synopsis

A model study for a novel approach to the synthesis of 2-carboxyinosines has been described. The synthesis of 9-benzyl-2-carboxyhypoxanthine (I), a model for 2-carboxyinosine, was achieved in four steps starting from 1-benzyl-5-nitroimidazole-4-carboxylic acid. Also reported is the synthesis of 9-benzyl-2,2bis(ethoxycarbonyl)hypoxanthine (II).

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