Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the
A model of the mechanism of cooperativity and associativity of long-term potentiation in the Hippocampus: a fundamental mechanism of associative memory and learning
โ Scribed by Tatsuo Kitajima; Ken-ichi Hara
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 631 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0340-1200
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โฆ Synopsis
Long-Term Potentiation (LTP) has three properties: (1) input specificity, (2) cooperativity and (3) associativity. In a previous paper, we proposed an integrated model of the mechanisms of the induction and maintenance of LTP with input specificity. In this paper, a model of the mechanism of cooperative and associative LTP is described. According to computer simulations of the model, its mechanism is based on the spread of synaptic potentials.
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