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A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene

✍ Scribed by Jeffrey K. Wickliffe; Marinel M. Ammenheuser; James J. Salazar; Sherif Z. Abdel-Rahman; Darlene A. Hastings-Smith; Edward M. Postlethwait; R. Stephen Lloyd; Jonathan B. Ward Jr.

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 166 KB
Volume: 42
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.10181

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Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene

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## Abstract The carcinogenic effects of 1,3‐butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH) enzyme. Th