A model of regional ventilation-perfusion inhomogeneity in the avian lung: Implications for gas exchange and intrapulmonary chemoreceptor microenvironment
✍ Scribed by S.C Hempleman; T.P Adamson; R.E Burger
- Publisher
- Elsevier Science
- Year
- 1983
- Weight
- 516 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0010-468X
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✦ Synopsis
We recorded discharge frequencies of 32 intrapulmonary chemoreceptors (IPC) during caudocranial and craniocaudal ventilation in the perfused duck lung. Blood gases, ventilatory gas flow, inspired Pco2 and Po2' and expired Pco2 measured simultaneously were used to predict regional CO 2 and 02 gradients within the lung. Gas exchange was modelled in 7 log normal ventilation perfusion compartments using mass balance differentials with an adjustable step size. CO 2 and 02 interactions during exchange were modelled using the Bohr effect, Pso, blood acid base status, and the CO 2 dissociation relationship. Close agreement ( + 1.0 Torr) between simulated arterial and expired Pco2 and observed values was achieved after forcing simulated Pao2 to converge on observed Pao, ~ by an iterative adjustment of the perfusive shunt or the log standard deviation of the ventilation-perfusion distribution. Using the 1PC static CO 2 sensitivity measured in the non-perfused lung and the CO 2 gradients generated by the model, we have found evidence for a distributed multi-ending receptor system in the duck lung.
Simulation, computer Respiration, avian Receptive field Control