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A model of promoter recognition along the two helical grooves of DNA

✍ Scribed by Valery I. Ivanov

Publisher
Springer
Year
1976
Tongue
English
Weight
450 KB
Volume
3
Category
Article
ISSN
0301-4851

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✦ Synopsis

Abstraet. A speculative model based on published sequences to explain the specific binding of RNA polymerase ofE. coli to promoters is suggested: mRNA \ j v 5'I, ,o,o,, I,, i ,D, ol, 1 i,, ,, I 3' I'o' ' 'o' I''' 'o'n I 'o'D' 'o' Io' ' ' ' 'o1 24 18 12 6 1

A fragment 24 base pairs long to the left of the initiation site must not contain the G's in the positions indicated by the circles and must contain T's (or G's) in the positions marked by the squares. In most known cases mutual disposition of the circle and square patterns is as shown above. In one case (the fd G3 promoter) the pattern of squares is shifted by 4 base pairs to the right relative to the pattern of universal non-G's (circles).

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