A model of muscle atrophy using cast immobilization in mice

✍ Scribed by Tiffany N. Frimel; Fatema Kapadia; Gabriel S. Gaidosh; Ye Li; Glenn A. Walter; Krista Vandenborne

• Book ID: 102539399
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 148 KB
• Volume: 32
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.20399

✦ Synopsis

Abstract

We describe a new cast‐immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains. Muscle Nerve, 2005