Irregularities in intracellular traffic in axons caused by mutations of molecular motors may lead to "traffic jams", which often result in swelling of axons causing such neurodegenerative diseases as Alzheimer's disease and Down syndrome. Hence, it is of particular interest to mathematically model t
A model of intracellular transport of particles in an axon
โ Scribed by Avner Friedman; Gheorghe Craciun
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 340 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0303-6812
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๐ SIMILAR VOLUMES
A model of fast axonal transport of organelles that accounts for dynein transport in an inactive state toward the axonal synapse is developed. It is assumed that anterograde transport of inactive dynein in an axon is powered by kinesin motors. It is further assumed that the probability of organelle
We present a model that predicts the maximum axonal length from the apparent velocity of slow axonal transport and cytoskeletal protein half-life. The model assumes that in mature axons the apparent velocity of slow transport varies with position, but that the density of cytoskeletal proteins and pr