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A model of a growing steady-state system with a changing surface-volume ratio

✍ Scribed by J.N.R. Grainger; P.E. Gaffney; T.T. West

Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
340 KB
Volume
21
Category
Article
ISSN
0022-5193

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Volume of distribution at steady state f
Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination
✍ Leonid M. Berezhkovskiy πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 156 KB πŸ‘ 1 views

The problem of finding the steady-state volume of distribution V ss for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V ss ΒΌ (D/AUC)\*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V ss