A model mouse: Can an accidental rodent strain unlock secrets of rheumatoid arthritis?

Presumptive role of 129 strain–derived S

Presumptive role of 129 strain–derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb–deficient C57BL/6 genetic background

✍ Aya Sato-Hayashizaki; Mareki Ohtsuji; Qingshun Lin; Rong Hou; Naomi Ohtsuji; Kei 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 703 KB

## Objective: Fcγ receptor type iib (fcγriib) is a major negative regulator of b cells, and the lack of fcγriib expression has been reported to induce systemic lupus erythematosus (sle) in mice of the c57bl/6 (b6) genetic background. the 129 strain-derived sle16 locus on the telomeric region of chr