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A model for the diastereofacial differentiation in the alkylation of endocyclic enolate

โœ Scribed by Tomioka, Kiyoshi.; Kawasaki, Hisashi.; Yasuda, Kosuke.; Koga, Kenji.


Book ID
120509997
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
752 KB
Volume
110
Category
Article
ISSN
0002-7863

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A rationale of diastereofacial selection
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Ratios of the diastereomers 4 and 5 in the alkylation of the endocyclic enolates 3 with chirality at the B-position were highly dependent on the steric bulkiness of R1 and R2. It was clarified that, when the allylic strain considerations are acknowledged in 3, the diastereofacial selection is succes

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