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A model for karyotypic evolution in testicular germ cell tumors

✍ Scribed by Attila Frigyesi; David Gisselsson; Gunnar B. Hansen; Maria Soller; Felix Mitelman; Mattias Höglund

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
128 KB
Volume
40
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Testicular germ cell tumor karyotypes are characterized by near‐triploidy, with chromosome numbers ranging from 50 to 70, and by the frequent appearance of i(12p). The high chromosome number has been attributed to the formation of tetraploid carcinoma in situ cells followed by chromosomal losses that ultimately lead to tumor forms that are more advanced. In the present investigation, we show by analysis of the accumulated cytogenetic data on testicular germ cell tumors and computer simulations that two distinct processes are operating in the karyotypic evolution of these tumors. The results suggest that whole‐chromosome changes originate from a multipolar cell division of a tetraploid cell, whereas imbalances caused by structural changes accumulate in a stepwise manner. © 2004 Wiley‐Liss, Inc.

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## Abstract ## BACKGROUND Recent reports have suggested that the increasing rates of testicular germ cell tumors in some populations have begun to plateau. This study was conducted to examine whether rates among white men in the United States have begun to stabilize and whether rates among black m