A model for fatigue generation and exercise prescription in multiple sclerosis patients
✍ Scribed by L. Tesio; L. Perucca; A. Bellafà
- Publisher
- Springer Milan
- Year
- 2006
- Tongue
- English
- Weight
- 106 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1590-1874
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## Abstract If fatigue in multiple sclerosis (MS) is related to an abnormal activation of the sensorimotor brain network, the activity of such a network should vary with varying fatigue. We studied 22 patients treated with interferon beta 1a (IFNβ‐1a; Avonex, Biogen, Cambridge, MA) with no fatigue
## Abstract Female SJL/J mice, suffering from experimental autoimmune encephalomyelitis (EAE), were injected with 1 × 10^7^ cells from a syngeneic fibroblast line transduced with a retroviral vector designed to encode proteolipid protein (101‐157) targeted for secretion. A striking abrogation of bo