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A Mixture Gatekeeping Procedure Based on the Hommel Test for Clinical Trial Applications

✍ Scribed by Brechenmacher, Thomas; Xu, Jane; Dmitrienko, Alex; Tamhane, Ajit C.

Book ID
120456910
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
311 KB
Volume
21
Category
Article
ISSN
1054-3406

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We present a new test for the presence of a normal mixture distribution, based on the posterior Bayes factor of Aitkin (1991). The new test has slightly lower power than the likelihood ratio test. It does not require the computation of the MLEs of the parameters or a search for multiple maxima, but