A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population
β Scribed by H. Shimomura; T. Sanke; K. Ueda; T. Hanabusa; S. Sakagashira; K. Nanjo
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 137 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0012-186X
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Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec