✦ LIBER ✦
A Mild Titanium-Catalyzed Synthesis of Functionalized Amino Coumarins as Fluorescence Labels
✍ Scribed by Lisa Wirtz; Uli Kazmaier
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 294 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
In contrast to Brønsted and other Lewis acids ClTi(O__i__Pr)~3~ is especially suited to catalyze the formation of amino‐substituted coumarins from aminophenols and functionalized β‐oxo esters in a Pechmann condensation. This straightforward protocol allows the synthesis of fluorescence labels and false fluorescent neurotransmitters.