A mild method for ring-opening aminolysis of lactones

✍ Scribed by Wenming Liu; David D Xu; Oljan Repič; Thomas J Blacklock

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 71 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00196-4

✦ Synopsis

A mild and general method for lactone aminolysis is reported. Sodium 2-ethylhexanoate (NaEH) is found to serve both as a base and a catalyst in aminolysis of a variety of lactones by benzylamine hydrochloride. The nearly neutral pH conditions make this method applicable to many acid/base sensitive substrates.