A Mild Chemospecific Reductive Dehalogenation of Ethylaminobenzamides with Lithium Aluminum Hydride. -Secondary N-(2aminoethyl)benzamides substituted at the ortho-position of the phenyl ring with halogen are dehalogenated at this position by treatment with LiAlH 4 at room temperature. The p-iodo de
A mild chemospecific reductive dehalogenation of ethylaminobenzamides with lithium aluminum hydride
โ Scribed by James A. Hendrix; David W. Stefany
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 199 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Although the rearrangement which occurs on reduction of aranat~c ketoximes with lithium aluminum hydride (equation la) Is well known, 192 the reductive rearrangement of aromatic aldoximes under similar conditions (equation lb) has not been reported, despite the fact that a mznber of aldoximes have b
Treatment of 2,3-epoxy acetals with lithium aluminum hydride gave the corresponding 2-hydroxy acetals, instead of the previously reported 3-hydroxy acetals.
Reduction of c-bromophenyl ally1 ether with LiAlH4 yields phenyl ally1 ether 3-methyl-2,3\_dihydrobenzofuran, thus suggesting the involvement of radical intermediates in reduction. and the Metal hydrides' are generally considered to react as nucleophilic hydride species. Reduction of the carbonyl gr