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A Mild and Highly Efficient Synthesis of Chiral N-Dichloroacetyl-4-ethyl-1,3-oxazolidines

✍ Scribed by Li-Xia Zhao; Ying Fu; Fei Ye; Shuang Gao


Book ID
115558843
Publisher
Journal of Heterocyclic Chemistry
Year
2012
Tongue
English
Weight
300 KB
Volume
49
Category
Article
ISSN
0022-152X

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Highly efficient and mild synthesis of v
✍ Michel Journet; Dongwei Cai; Jason J Kowal; Robert D Larsen πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 51 KB

Ph TBSO(CH 2 ) 3 THPO(CH 2 ) 2 THPOCH 2 TBSOCH 2 n-C 4 H 9 R 1) 1 equiv n-BuLi; THF; -40 ΒΊC 2) 2 equiv DMF; -40 ΒΊC to r.t.; 0.5h 3) "Reverse" 10% aq. KH 2 PO 4 (4 equiv); MTBE; 5 ΒΊC (Ref. 9) 1 2 (a) (a) Position of the triazole NH is arbitrarily assigned since we cannot differentiate reliably betwee