✦ LIBER ✦
A Mild and Efficient Method for N-Arylnucleobase Synthesis via the Cross-Coupling Reactions of Nucleobases with Arylboronic Acids Catalyzed by Simple Copper Salts
✍ Scribed by Lan Tao; Yang Yue; Ji Zhang; Shan-Yong Chen; Xiao-Qi Yu
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- German
- Weight
- 176 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A simple and efficient copper‐salt catalyzed N‐arylation of nucleobases is reported. In a mixed solvent of MeOH and H~2~O, the coupling products were obtained in moderate to excellent yields at room temperature within a short time. A variety of substituted N‐aryl nucleobases can be prepared through this procedure.