A mild and efficient biomimetic synthesis of α-hydroxymethylarylketones from oxiranes in the presence of β-cyclodextrin and NBS in water

✍ Scribed by M. Arjun Reddy; N. Bhanumathi; K. Rama Rao

• Book ID: 104250856
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 49 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00433-1

✦ Synopsis

a-Hydroxymethylarylketones can be synthesized in good yields from easily accessible epoxides in the presence of b-cyclodextrin and NBS in water. This method is a direct, one-pot, synthesis under mild conditions using water as solvent and has many advantages over existing methodologies.