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A mild and efficient approach for the regioselective silyl-mediated protection–deprotection of C-4 hydroxyl group on carbohydrates

✍ Scribed by Andrea Graziani; Pietro Passacantilli; Giovanni Piancatelli; Simona Tani


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
62 KB
Volume
42
Category
Article
ISSN
0040-4039

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✍ Matteo Adinolfi; Gaspare Barone; Luigi Guariniello; Alfonso Iadonisi 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 55 KB

Alkoxycarbonyl groups can be readily installed on carbohydrates by reaction with the corresponding chloroformates in the presence of TMEDA at low temperature. The mild reaction conditions can be modulated to attain regioselective protections.