A combined pharmacokinetic–pharmacodynam
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Jong Hwan Sung; Anjali Dhiman; Michael L. Shuler
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Article
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2009
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John Wiley and Sons
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English
⚖ 295 KB
A combined pharmacokinetic-pharmacodynamic model was developed to simulate the response of a rat tumor to UFT, a combination of uracil with Tegafur (FT). Tegafur is oral the prodrug of 5-fluorouracil (5-FU), an anti-cancer drug for colon cancer. A physiologically based pharmacokinetic (PBPK) model w