A microdialysis investigation of the release of norepinephrine in the hypothalamus induced by 2-deoxyglucose in awake rats
β Scribed by A. I. Kuz'min; M. B. Bogdanov; O. S. Medvedev
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 481 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0097-0549
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To clarify the controversy concerning the role of catecholaminergic systems in regulating hypothalamic corticotropin-releasing factor (CRF) secretion, we assessed the direct effects of norepinephrine and epinephrine, alone and in association with mixed a and p antagonists on hypothalamic CRF secreti
The microdialysis technique was used to study the in vivo extracellular levels of norepinephrine in the bed nucleus of the stria terminalis. A basal level of 2.34 +/-0.25 fmol/microl of norepinephrine was observed. Desipramine (2 and 10 microM), a norepinephrine uptake blocker, significantly increas