A Microcarrier-Based Cultivation System for Expansion of Primary Mesenchymal Stem Cells
β Scribed by Simone Frauenschuh; Elisabeth Reichmann; Yvonne Ibold; Peter M. Goetz; Michael Sittinger; Jochen Ringe
- Book ID
- 109387463
- Publisher
- American Institute of Chemical Engineers
- Year
- 2007
- Tongue
- English
- Weight
- 337 KB
- Volume
- 23
- Category
- Article
- ISSN
- 8756-7938
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Mesenchymal stem cells (MSCs) are considered as emergent ''universal'' cells and various tissue repair programs using MSCs are in development. In vitro expansion of MSCs is conventionally achieved in medium containing fetal calf serum (FCS) and is increased by addition of growth factors. However, fo
## Abstract This work presents a simple membraneβbased microfluidic chip for the investigation of proliferation and differentiation of mesenchymal stem cells (MSCs) under mechanical stimuli. The cyclic tensile stress was generated by the deformation of elastic PDMS membrane sandwiched between the t