A Microassay for Measuring Cytochrome P450IA1 and Cytochrome P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates

Effect of silybin and its glycosides on

Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes

✍ Pavel Kosina; Patrick Maurel; Jitka Ulrichová; Zdeněk Dvořák 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 1 views

## Abstract Four β‐glycosides of flavonoligan silybin, i.e. silybin β‐galactoside, silybin β‐glucoside, silybin β‐maltoside, silybin β‐lactoside were synthesized in order to improve silybin water solubility and bioavailability (Křen et al., J Chem Soc, Perkin Trans 1, 2467–2474, 1997). The presente