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A Methylation-Dependent DNA-Binding Activity Recognising the Methylated Promoter Region of the MouseXistGene

✍ Scribed by John Huntriss; Roberto Lorenzi; Amarjit Purewal; Marilyn Monk

Book ID
115580472
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
450 KB
Volume
235
Category
Article
ISSN
0006-291X

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## Abstract Changes in DNA methylation patterns are frequently observed in human cancers and are associated with a decrease in tumor suppressor gene expression. Hypermethylation of the __BRCA1__ promoter has been reported in a portion of sporadic breast tumours that correspond to a reduction in __B