✦ LIBER ✦

A method of computing drug distribution in plasma using stepwise association constants: Clofibrate acid as an illustrative example

✍ Scribed by Walter D. Wosilait; Paul Nagy

Publisher: Elsevier Science
Year: 1976
Weight: 369 KB
Volume: 6
Category: Article
ISSN: 0010-468X
DOI: 10.1016/0010-468x(76)90020-9

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✦ Synopsis

A program is described to compute the distribution of ligand among various complexes of ligand and protein using stepwise association constants. The key input data consists of stepwise association constants and the concentration of macromolecule and various concentrations of ligand. The key output data consists of the concentration of free drug and protein and the concentration of the various complexes. stepwise association constants drug-protein binding clofibrate

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✍ Walter D. Wosilait; Paul Nagy 📂 Article 📅 1976 🏛 Elsevier Science ⚖ 299 KB

This paper describes a computer program for estimating the amount of free or unbound ligand in the plasma as well as the distribution of the ligand among different sets of binding sites on different proteins. The input data consists of: the number and concentrations of proteins involved, the number