A method for removal of N-BOC protecting groups from substrates on TFA-sensitive resins

✍ Scribed by Alex J Zhang; David H Russell; Jieping zhu; Kevin Burgess

• Book ID: 104259940
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 245 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01631-1

✦ Synopsis

NoTert-butyloxycarbonyl groups can be removed from substrates supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-1utidine. This methodology was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small molecule libraries.