A method for generating nitrile oxides from nitroalkanes: a microwave assisted route for isoxazoles

✍ Scribed by Giampaolo Giacomelli; Lidia De Luca; Andrea Porcheddu

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 174 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00859-7

✦ Synopsis

A convenient route has been developed for generation of nitrile oxides in situ from nitroalkanes under very mild conditions using microwave irradiation, using 4-(4,6-dimethoxy[1,3,5]triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) and DMAP as catalyst. Isoxazolines and isoxazoles are obtained in very good yields compared to known methods.