Optimal designs for estimating penetranc
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Gail Gong; Alice S. Whittemore
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Article
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2003
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John Wiley and Sons
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English
β 109 KB
## Abstract Many clinical decisions require accurate estimates of disease risks associated with mutations of known diseaseβsusceptibility genes. Such risk estimation is difficult when the mutations are rare. We used computer simulations to compare the performance of estimates obtained from two type