A METHOD FOR DETERMINING THE SIZE OF INT
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LEIV SANDVIK; JAN ERIKSSEN; PETTER MOWINCKEL; EINAR ANDREAS RΓDLAND
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Article
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1996
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John Wiley and Sons
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English
β 266 KB
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The assessment of sample size in clinical trials comparing population means requires a variance estimate of the main efficacy variable. When this variance estimate has a low precision, it may be appropriate to use the data from the first patients entered in the trial ('internal pilot study') to esti