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A metal-mediated diastereoselective synthesis of precursors to the aphid pigment derivatives

✍ Scribed by Robin G.F. Giles; Cynthia A. Joll; Melvyn V. Sargent; D.Matthew G. Tilbrook


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
255 KB
Volume
37
Category
Article
ISSN
0040-4039

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The total diastereoselective synthesis of the C,D rings/side chain building block for the synthesis of 1Ξ±,25-dihydroxyvitamin D 3 is described. Two tandem Mukaiyama-Michael additions involving silylated ketene acetals derived from tert-butyl 6-methylhept-5-enethioate or tert-butyl 6-methylhept-6enet