A metabolic inhibition test for titration of antibody to arboviruses adapted to mouse embryo cell culture
โ Scribed by J. B. Wilterdink; J. Versteeg
- Publisher
- Springer Vienna
- Year
- 1965
- Tongue
- English
- Weight
- 469 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1432-8798
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A series of eight tritium-labelled polycyclic hydrocarbons were incubated in the presence of monolayer cultures of primary mouse embryo cells, and the time-course of their metabolism to water-soluble derivatives was studied. All the hydrocarbons, both carcinogenic and non-carcinogenic, were metaboli
## Abstract The metabolism of tritiated benzo[a]pyrene (B[a]P) by primary mouse embryo cells in culture was studied. At concentrations of B[a]P in the medium below about 2โ3 mฮผ moles/ml, metabolism was exponential with time, but at higher concentrations a period of rapid metabolism was followed by