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A meta-analysis of trials of pulmonary hypertension: A clinical condition looking for drugs and research methodology

✍ Scribed by Alejandro Macchia; Roberto Marchioli; RosaMaria Marfisi; Marco Scarano; Giacomo Levantesi; Luigi Tavazzi; Gianni Tognoni


Book ID
116190908
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
526 KB
Volume
153
Category
Article
ISSN
1097-6744

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Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert