## Abstract Different lines of evidence indicate that methylenetetrahydrofolate reductase (__MTHFR__) functional gene polymorphisms, causative in aberrant folateโhomocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Opposing views are exp
A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk
โ Scribed by Sarah J. Lewis; Stanley Zammit; David Gunnell; George Davey Smith
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 55 KB
- Volume
- 135B
- Category
- Article
- ISSN
- 1552-4841
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๐ SIMILAR VOLUMES
Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme
## Abstract Methylenetetrahydrofolate reductase (MTHFR) is a vital enzyme catalyzing the nicotinamide adenine dinucleotide phosphate (NADPH) linked reduction of 5,10โmethylenetetrahydrofolate to 5โmethylenetetrahydrofolate, which serves as cofactor in methylation of homocysteine to methionine. Thre