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A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate synthetase

✍ Scribed by Moran, Richard G.; Colman, Paul D.; Forsch, Ronald A.; Rosowsky, Andre


Book ID
120548900
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
678 KB
Volume
27
Category
Article
ISSN
0022-2623

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## Abstract We have studied the molecular basis of drug resistance in human CCRF‐CEM leukemia cells exposed to high dose intermittent pulses of novel polyglutamatable antifolates that target various folate‐dependent enzymes. These include the dihydrofolate reductase (DHFR) inhibitors edatrexate, me