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A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens

✍ Scribed by Lacroix, Jérôme; Poët, Mallorie; Maehrel, Céline; Counillon, Laurent


Book ID
110032392
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
163 KB
Volume
5
Category
Article
ISSN
1469-221X

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Mechanism of activation of the NA+/H+ ex
✍ M. Sawkat Anwer 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 931 KB

Arginine vasopressin has been shown to activate the Na+/H+ exchanger in hepatocytes by calcium/calmodulin-dependent processes. Whether this activation also involves protein kinase C and is associated with changes in the intracellular pH setpoint was investigated in this study. Changes in pHi and int