A mathematical model to quantitate histamine release from basophils challenged in vitro with insect venom
✍ Scribed by James A. Hokanson; J.Andrew Grant; Michael Lett-Brown; R.Allen White
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 686 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0010-4825
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✦ Synopsis
Using a two parameter mathematical model, it was possible to describe clinically obtained data from histamine release (HR) in oitro as a response to basophils challenged by insect venom. The Gompertz function used in this model not only reflects the observed HR data but can be used to predict maximal HR values from initial lower antigen concentrations HR determinations. The model was used to calculate the concentration of venom antigens releasing 25% of total intracellular histamine (HR25). This is clinically significant in that while knowledge of the HR25, or any other reference fraction, facilitates comparisons between allergic patients, it is impossible to empirically administer venom antigen concentrations that will produce exactly HR25 in a given clinical setting.
Histamine release Allergic reaction Mathematical model Gompertz function Predictive response
Clinically