A mathematical model of the trafficking of acid-dependent enveloped viruses: Application to the binding, uptake, and nuclear accumulation of baculovirus
✍ Scribed by Kennie U. Dee; Michael L. Shuler
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 479 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0006-3592
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✦ Synopsis
A quantitative understanding of virus trafficking rovirus which is being considered for gene therapy. We would be useful in treating viral-mediated diseases, deare primarily interested in developing general models veloping protocols for viral gene therapy, designing infecfor enveloped viruses. tion regimens for viral expression systems, and optimiz-To infect eucaryotic cells, enveloped viruses must ining vaccine and recombinant protein production. Here, troduce their genome into the cytosol by membrane
we present a mathematical model of the attachment, infusion (White et al., 1983). Fusion can occur at the ternalization, endosomal fusion, lysosomal routing, and nuclear accumulation of baculovirus in SF21 insect cells.