✦ LIBER ✦

A mathematical model of the mechanism of vertebrate somitic segmentation

✍ Scribed by A.A. Polezhaev

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 811 KB
Volume: 156
Category: Article
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(05)80671-x

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✦ Synopsis

A mathematical model for the mechanism of periodic pattern formation in the process of somitogenesis is proposed. It is assumed that the metameric arrangement first appears before somite formation at the stage of transition of mesodermal cells into a polarized state. The model is based on the assumption that besides the mechanism of contact cell polarization there exists a mechanism of polarization suppression clue to excretion of some chemical substance by polarized cells. Periodicity appears as a result of interaction of a kinematic wave of somitogenic cell determination with the cell cycles of mesodermal cells.

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